Mioli V, Tarchini R, Boggi R, and et al. Tarighat, Esfanjani A., Mahdavi, R., Ebrahimi, Mameghani M., Talebi, M., Nikniaz, Z., and Safaiyan, A. View abstract. Acta Paediatr 1996;85:446-9. Our website services, content, and products are for informational purposes only. View abstract. In one study, 2 grams of L-carnitine reduced fatigue and increased muscle function in older adults. View abstract. Srivastava DK, Kumar S Misra AP. Ghidini O, Azzurro M, Vita G, Sartori G. Evaluation of the therapeutic efficacy of L-carnitine in congestive heart failure. It is made by your body and also available as a supplement. Minerva Anestesiol. Harper, P., Elwin, C. E., and Cederblad, G. Pharmacokinetics of intravenous and oral bolus doses of L-carnitine in healthy subjects. J Med.Food 2006;9(4):468-473. View abstract. [Reduction of hospitalization thanks to L-carnitine in hemodialyzed patients]. Gorostiaga, E. M., Maurer, C. A., and Eclache, J. P. Decrease in respiratory quotient during exercise following L-carnitine supplementation. In cells, it helps transport fatty acids into the mitochondria, where they can be burned for energy. If you have one of these conditions, a supplement may be beneficial (1, 66, 67). Bodea, F., Bocea, A., and Decea, N. [L-carnitine decreases oxidative stress induced by experimental hypobaric hypoxia]. View abstract. CONDITIONS OF USE AND IMPORTANT INFORMATION: This information is meant to supplement, not replace advice from your doctor or healthcare provider and is not meant to cover all possible uses, precautions, interactions or adverse effects. View abstract. Newer research illustrates the potential benefits of carnitines different forms, which may be used for various conditions, including heart and brain diseases (22, 23). J Inherit.Metab Dis 2007;30(1):5-22. 2013 Sep;67(7):659-63. View abstract. Xue, Y. 2009;10(2):103-110. L-Carnitine supplementation in older women. Do not take this medicine in larger or smaller amounts or for longer than recommended. Int J Clin Pharmacol Res 1990;10:75-9. Corbucci, G. G., Melis, A., Piga, M., Marchionni, A., and Calvani, M. Influence of acetyl-carnitine on some mitochondrial enzymic activities in the human cerebral tissue in conditions of acute hypoxia. 2010;68(5):743-752. Zhang, Y., Song, J. Q., Liu, P., Yan, R., Dong, J. H., Yang, Y. L., Wang, L. F., Jiang, Y. W., Zhang, Y. H., Qin, J., and Wu, X. R. [Clinical studies on fifty-seven Chinese patients with combined methylmalonic aciduria and homocysteinemia]. Older adults may also benefit from L-carnitine supplements. Morgante, G., Scolaro, V., Tosti, C., Di, Sabatino A., Piomboni, P., and De, Leo, V. [Treatment with carnitine, acetyl carnitine, L-arginine and ginseng improves sperm motility and sexual health in men with asthenopermia]. Potential role of levocarnitine supplementation for treatment of chemotherapy-induced fatigue in non-anemic cancer patients. View abstract. 1995;146(12):769-774. Block, K. I., Koch, A. C., Mead, M. N., Tothy, P. K., Newman, R. A., and Gyllenhaal, C. Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials. Med Sci Sports Exerc. Kubota K, Uojima H, Shao X, et al. Genger, H., Enzelsberger, H., and Salzer, H. [Carnitine in therapy of placental insufficiency--initial experiences]. Our experts continually monitor the health and wellness space, and we update our articles when new information becomes available. Maestri, A., De Pasquale, Ceratti A., Cundari, S., Zanna, C., Cortesi, E., and Crino, L. A pilot study on the effect of acetyl-L-carnitine in paclitaxel- and cisplatin-induced peripheral neuropathy. Oncologist. Additional L-carnitine Reduced the Risk of Hospitalization in Patients with Overt Hepatic Encephalopathy on Rifaximin. L-Carnitine is not expected to harm an unborn baby. Drugs Exp Clin Res 1992;18:355-65. View abstract. Available for Android and iOS devices. Superiority of L-propionylcarnitine vs L-carnitine in improving walking capacity in patients with peripheral vascular disease: an acute, intravenous, double-blind, cross-over study. More studies on the safety of L-carnitine supplements are needed. Baek SM, Zheng R, Seo EJ, Hwang DY, Kim BH. Brand names: Carnitor, L-Carnitine Effect of L-carnitine on human immunodeficiency virus-1 infection-associated apoptosis: a pilot study. View abstract. Kosolcharoen T, Nappi J, Peduzzi P, and et al. Acute effect on satiety, resting energy expenditure, respiratory quotient, glucagon-like peptide-1, free fatty acids, and glycerol following consumption of a combination of bioactive food ingredients in overweight subjects. Online ahead of print. Seattle, WA: University of Washington, Seattle;1993. The study in the European Heart Journal involved 113 healthy men and women to determine the effect of consuming red meat and white meat . J Inherit.Metab Dis 2008;31 Suppl 2:S453-S456. Cochrane.Database.Syst.Rev. Sangouni AA, Pakravanfar F, Ghadiri-Anari A, Nadjarzadeh A, Fallahzadeh H, Hosseinzadeh M. The effect of L-carnitine supplementation on insulin resistance, sex hormone-binding globulin and lipid profile in overweight/obese women with polycystic ovary syndrome: a randomized clinical trial. 7 Best Creatine Supplements for Women in 2023: A Dietitians Picks. Propionyl-L-carnitine: Studies have shown that propionyl-L-carnitine combined with Viagra might improve erectile function better than sildenafil alone. View abstract. View abstract. Volek, J. S., Judelson, D. A., Silvestre, R., Yamamoto, L. M., Spiering, B. (pre-publication author's copy, via correspondence) 2002;1-14. View abstract. Clinico- experimental, prospective, sequential study]. Liu J, Head E, Kuratsune H, et al. Neurol.India 2008;56(3):391-393. Kidney Int 38 (1990): 904-11, 4. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Pettegrew JW, Klunk WE, Panchalingam K, et al. Chan, A., Remington, R., Kotyla, E., Lepore, A., Zemianek, J., and Shea, T. B. View abstract. L-carnitine might increase the effects of warfarin and increase the chances of bruising and bleeding. L-carnitine supplementation of a soybean-based formula in early infancy: plasma and urine levels of carnitine and acylcarnitines. You may report them to the FDA. View abstract. Clin Lymphoma Myeloma Leuk. Lee, P. J., Harrison, E. L., Jones, M. G., Jones, S., Leonard, J. V., and Chalmers, R. A. L-carnitine and exercise tolerance in medium-chain acyl-coenzyme A dehydrogenase (MCAD) deficiency: a pilot study. Verrina, E., Caruso, U., Calevo, M. G., Emma, F., Sorino, P., De, Palo T., Lavoratti, G., Turrini, Dertenois L., Cassanello, M., Cerone, R., and Perfumo, F. Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis. View abstract. Suzuki, Y., Narita, M., and Yamazaki, N. Effects of L-carnitine on arrhythmias during hemodialysis. Chen, J. C., Tsai, T. C., Liu, C. S., and Lu, C. T. Acute hearing loss in a patient with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). View abstract. Nephrol.Dial Transplant 2008;23(3):991-997. View abstract. Spagnoli A, Lucca U, Menasce G, et al. Roy, M. J., Dionne, S., Marx, G., Qureshi, I., Sarma, D., Levy, E., and Seidman, E. G. In vitro studies on the inhibition of colon cancer by butyrate and carnitine. It specifically emphasizes upon the beneficial role of l-carnitine in cardiomyopathy. View abstract. Nephrologie 1998;19:171. Uzun, N., Sarikaya, S., Uluduz, D., and Aydin, A. Peripheric and automatic neuropathy in children with type 1 diabetes mellitus: the effect of L-carnitine treatment on the peripheral and autonomic nervous system. View abstract. Rausch CR, Paul S, Marx KR, et al. Coulter DL. View abstract. Some studies demonstrate a potential for reducing blood pressure and the inflammatory process associated with heart disease (23, 39). 2012;7(11):1836-1842. "The first study found that people who ate a lot of red meat had a certain type of bacteria in their system that broke the compound down into TMAO and raised their risk for heart disease," he explained. View abstract. View abstract. View abstract. Mild myasthenia has occurred in uremic patients receiving D,L-carnitine (but not levocarnitine). [Ref], There have been reports from clinical trials of significant increases in platelet aggregation associated with high doses of levocarnitine (the active ingredient contained in L-Carnitine) (3 g/day) given to hemodialysis patients. Comparative study of bioactive constituents in crude and processed Glycyrrhizae radix and their respective metabolic profiles in gastrointestinal tract in vitro by HPLC-DAD and HPLC-ESI/MS analyses. Perrott, J., Murphy, N. G., and Zed, P. J. L-carnitine for acute valproic acid overdose: a systematic review of published cases. Am J Mens Health 2021;15(5):15579883211036790. View abstract. J.Reprod.Infertil 2010;10(4):245-251. Drugs Exp Clin Res 1984;10(4):219-223. Graziano F, Bisonni R, Catalano V, et al. A., Servan-Schreiber, D., Panchalingam, K., and McClure, R. J. Zhonghua Nan.Ke.Xue 2012;18(5):428-431. Heringer, J., Boy, S. P., Ensenauer, R., Assmann, B., Zschocke, J., Harting, I., Lucke, T., Maier, E. M., Muhlhausen, C., Haege, G., Hoffmann, G. F., Burgard, P., and Kolker, S. Use of guidelines improves the neurological outcome in glutaric aciduria type I. Ann.Neurol. In a preliminary analysis, we reported that L-carnitine could improve fatigue, mood and sleep. Drugs Aging 2006;23(3):263-270. A. Acetyl-L-carnitine for the treatment of diabetic peripheral neuropathy. B., Abdenur, J. E., and Wing, D. A. Carnitine deficiency in pregnancy. Acta Urol Ital 1996;10(3):185-187. [Infantile encephalopathy associated with the MELAS A3243G mutation. Effect of lysine, vitamin B(6), and carnitine supplementation on the lipid profile of male patients with hypertriglyceridemia: a 12-week, open-label, randomized, placebo-controlled trial. Eur.J Gastroenterol.Hepatol. View abstract. View abstract. 2018 Jun;20(3):285-290. 2016;15:107. View abstract. Derosa, G., Cicero, A. F., Gaddi, A., Mugellini, A., Ciccarelli, L., and Fogari, R. The effect of L-carnitine on plasma lipoprotein(a) levels in hypercholesterolemic patients with type 2 diabetes mellitus. View abstract. L-Carnosine is known as the ' longevity molecule'. Low Blood Pressure. Prevention of hepatotoxicity recurrence with valproate monotherapy and carnitine. L-Carnitine should be taken at evenly spaced intervals every 3 or 4 hours. El Beshlawy, A., Mohtar, G., Abd El, Ghafar E., Abd El Dayem, S. M., El Sayed, M. H., Aly, A. View abstract. (Tokyo) 2001;47(6):378-384. This makes L-carnitine a conditionally essential nutrient (6). Curr Opin Clin Nutr Metab Care 2000;3:417-24. Haghighatdoost F, Jabbari M, Hariri M. The effect of L-carnitine on inflammatory mediators: a systematic review and meta-analysis of randomized clinical trials. HIV.Med. Carnitine, valproate, and toxicity. View abstract. Swoboda, K. J., Scott, C. B., Crawford, T. O., Simard, L. R., Reyna, S. P., Krosschell, K. J., Acsadi, G., Elsheik, B., Schroth, M. K., D'Anjou, G., LaSalle, B., Prior, T. W., Sorenson, S. L., Maczulski, J. View abstract. Yet, there are a few known side effects that include agitation, insomnia and nausea. View abstract. Talenezhad N, Mohammadi M, Ramezani-Jolfaie N, Mozaffari-Khosravi H, Salehi-Abargouei A. View abstract. View abstract. Goodison G, Overeem K, de Monte V, Siskind D. Mania associated with self-prescribed acetyl-l-carnitine in a man with bipolar I disorder. Musso, G., Gambino, R., Cassader, M., and Pagano, G. A meta-analysis of randomized trials for the treatment of nonalcoholic fatty liver disease. View abstract. Intravenous L-carnitine increases plasma carnitine, reduces fatigue, and may preserve exercise capacity in hemodialysis patients. Chinese J.Clin.Healthcare 2008;11(5):478-480. [Ref], Very common (10% or more): Anemia (12%)[Ref], Common (1% to 10%): Kidney failure (chronic hemodialysis patients)[Ref], Common (1% to 10%): Parathyroid disorder[Ref], Very common (10% or more): Pharyngitis (27%), cough increase (18%), dyspnea (11%), rhinitis (11%), Common (1% to 10%): Bronchitis, sinusitis[Ref], Common (1% to 10%): Amblyopia, eye disorder[Ref], Common (1% to 10%): Urinary tract infection[Ref], Very common (10% or more): Hypertension (21%), hypotension (19%), Common (1% to 10%): Atrial fibrillation, arrhythmia, cardiovascular disorder, electrocardiogram abnormal, palpitations, tachycardia, vascular disorder[Ref], Common (1% to 10%): Allergic reaction[Ref], Common (1% to 10%): Depression, anxiety, drug dependence, insomnia[Ref], Very common (10% or more): Infection (24%)[Ref]. A double-blind randomized study. View abstract. Acta Chir Scand Suppl 1983;517:157-164. Reprod Biol Endocrinol 2018;16(1):5. Scand.J Clin Lab Invest 1985;45(2):169-178. . View abstract. Nikolaos, S., George, A., Telemachos, T., Maria, S., Yannis, M., and Konstantinos, M. Effect of L-carnitine supplementation on red blood cells deformability in hemodialysis patients. J Child Neurol. Thom H, Carter PE, Cole GF, et al. View abstract. Int J Curr Res Acad Rev 2015;3:469-76. Eur Heart J 1989;10(6):502-508. 2007;19(2):206-210. A. Clinical Trials Journal 1986;23(4):242-248. Orlandi, A., Francesconi, A., Ferlosio, A., Di, Lascio A., Marcellini, M., Pisano, C., and Spagnoli, L. G. Propionyl-L-carnitine prevents age-related myocardial remodeling in the rabbit. L-carnitine is a nutrient and dietary supplement. Dig.Dis Sci 2006;51(12):2242-2247. View abstract. 2010;16(10):919-921. View abstract. The effects of anti-anxiety and depression therapy on life quality of patient with coronary heart disease. Res.Dev.Disabil. You may report side effects to FDA at 1-800-FDA-1088. Infusionsther.Klin.Ernahr. 11-15-2008;102(10):1413-1417. Arch.Gerontol.Geriatr. View abstract. View abstract. Corsi, C., Pollastri, M., Marrapodi, E., Leanza, D., Giordano, S., and D'Iddio, S. L-propionylcarnitine effect on postexercise and postischemic hyperemia in patients affected by peripheral vascular disease. For your body to produce it in sufficient amounts, you also need plenty of vitamin C (4). Gentile V, Vicini P, Prigiotti G, et al. 2007;52(6):1768-1774. Lisinopril (lisinipril) should be stopped if there are symptoms or signs of an allergic reaction including feelings of swelling of the face, lips, tongue or throat. View abstract. Int Urol Nephrol 2021;53(10):2149-2158. View abstract. Pediatr.Neurol. Santo, S. S., Sergio, N., Luigi, D. P., Giuseppe, M., Margherita, F., Gea, O. C., Roberto, F., Gabriella, C., Giuseppe, P., and Massimiliano, A. Efficacy of L-propionylcarnitine treatment in patients with left ventricular dysfunction. View abstract. Safarinejad, M. R., Hosseini, S. Y., and Kolahi, A. Warady, B. Background and aim: Clinical evidence which investigated the effects of l-carnitine, a vitamin-like substance, on weight loss had led to inconsistent results. Siriraj Med.J. View abstract. Mitwalli A, Wakeel J Alam A Tarif N Abu-Afsha A. Drug Dev Res 1988;14:213-216. Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat. Zhang, W., Miao, J., Zhang, G., Liu, R., Zhang, D., Wan, Q., Yu, Y., Zhao, G., and Li, Z. Scand.J Clin Lab Invest 1985;45(3):193-198. Novak M. Carnitine supplementation in soy-based formula-fed infants. Effects of wuzi yanzong liquids combing with L-carnitine on oligospermia and asthenospermia. View abstract. Pediatr.Endocrinol.Diabetes Metab 2010;16(2):78-81. Sethumadhavan, S. and Chinnakannu, P. Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. L-Carnitine in the treatment of fatigue in adult celiac disease patients: a pilot study. Kurul S, Dirik E, Iscan A. Serum carnitine levels during oxcarbazepine and carbamazepine monotherapies in children with epilepsy. Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Multi-Country Hepatitis Outbreak in Children, Needle-Free Epinephrine Options Are On The Horizon, Longer Vaccine Interval May Boost Antibodies 9 Times, How Walmart Is Rethinking Health (Medscape video), Dr. Whyte's Book: Take Control of Your Diabetes Risk. The easiest way to lookup drug information, identify pills, check interactions and set up your own personal medication records. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment. View abstract. Malaguarnera, M., Gargante, M. P., Russo, C., Antic, T., Vacante, M., Malaguarnera, M., Avitabile, T., Li, Volti G., and Galvano, F. L-carnitine supplementation to diet: a new tool in treatment of nonalcoholic steatohepatitis--a randomized and controlled clinical trial. According to the University of Maryland Medical Center, carnitine is successful in treating hyperthyroidism possibly because of its ability to block the effects of thyroid hormones - a potentially dangerous effect for people suffering from an underactive thyroid. Spasov, A. Vegans or people with certain genetic issues may be unable to produce or obtain enough. L-carnitine: a way to decrease cellular toxicity of ifosfamide? Greco, A. V., Mingrone, G., Bianchi, M., and Ghirlanda, G. Effect of propionyl-L-carnitine in the treatment of diabetic angiopathy: controlled double blind trial versus placebo. Mol.Psychiatry 2012;17(3):290-314. View abstract. Sabry, A. 2002;2(3):240-243. 2007;45(12):932-936. 2011;(6):CD003917. View abstract. Stanley CA. View abstract. Cardiologia 1989;34(7):651-655. Interestingly, food sources of L-carnitine have a greater absorption rate than supplements. Carlsson, M., Forsberg, E., and Thorne, A. Observations during L-carnitine infusion in two long-term critically ill patients. Insomnia; Diarrhea; Some . Hatamkhani S, Khalili H, Karimzadeh I, Dashti-Khavidaki S, Abdollahi A, Jafari S. Carnitine for prevention of antituberculosis drug-induced hepatotoxicity: a randomized, clinical trial. View abstract. Call your doctor at once if you have: a seizure (convulsions). The Effects of L-Carnitine, Acetyl-L-Carnitine, and Propionyl-L-Carnitine on Body Mass in Type 2 Diabetes Mellitus Patients. J Psychiatr.Pract. Early Hum.Dev. Int J Clin Pharmacol Res 1983;3(3):179-184. 1987;24(1):23-28. View abstract. Soyucen, E., Demirci, E., and Aydin, A. Outpatient treatment of propionic acidemia-associated hyperammonemia with N-carbamoyl-L-glutamate in an infant. J Am Coll Nutr. View abstract. Yet, there are a few known side effects that include agitation, insomnia and nausea. 2008;(2):CD003917. J Autism Dev.Disord. J Eur Acad Dermatol Venereol. View abstract. View abstract. Eroglu, H., Senel, O., and Guzel, N. A. Your body can produce L-carnitine out of the amino acids lysine and methionine. Maccio, A., Madeddu, C., Gramignano, G., Mulas, C., Floris, C., Sanna, E., Cau, M. C., Panzone, F., and Mantovani, G. A randomized phase III clinical trial of a combined treatment for cachexia in patients with gynecological cancers: evaluating the impact on metabolic and inflammatory profiles and quality of life. Expert.Opin.Pharmacother. Vasc.Med 2012;17(3):145-154. 2010;58(5):551-565. Stuessi, C., Hofer, P., Meier, C., and Boutellier, U. L -Carnitine and the recovery from exhaustive endurance exercise: a randomised, double-blind, placebo-controlled trial. Ann Neurol 1994;35:482-7. Alternative medical interventions used in the treatment and management of myalgic encephalomyelitis/chronic fatigue syndrome and fibromyalgia. View abstract. Z., and McIntyre, R. S. Acetyl-L-carnitine and alpha-lipoic acid: possible neurotherapeutic agents for mood disorders? I tried this recently at a low dose, 125 mg, and had strong side effects for a day or two. View abstract. Here are several other types of carnitine: For most people, acetyl-L-carnitine and L-carnitine seem to be the most effective for general use. Eur.Neuropsychopharmacol. Diabetes Care 2005;28:89-94. Miles, C. L., Candy, B., Jones, L., Williams, R., Tookman, A., and King, M. Interventions for sexual dysfunction following treatments for cancer.